This study was conducted to investigate the variables associated with satisfaction of use of the SPeCTRUM e-learning platform of Universiti Malaya among engineering students. Two domains were investigated, namely, student characteristics (computer attitude, perceived usefulness and computer self-efficacy and system characteristics (system functionality, infrastructure and technical support). A questionnaire, specially developed using items adopted from previous related studies, was used to elicit responses. Item-structure analysis of the questionnaire revealed high reliability. The sample was 70 engineering students of Universiti Malaya. The findings revealed that system functionality (β=0.649, p<0.001), perceived ease of use (β=0.242, p<0.05) and attitude to use (β=0.150, p<0.05) were found to be strong predictors and determinants of satisfaction of use. Computer self-efficacy (β=-0.101), infrastructure (β=0.067) and technical support (β=0.014) were not significantly related to satisfaction of use. The total variance explained was 88.7% suggesting a good model of fit. Implications of the findings in terms of the intervention required to ensure the satisfaction of use are discussed.