In this recent day, information technology becomes prominent to support teaching and learning activities. E-learning also known as online learning was one of information technology (IT) tools introduced at College of Science and Technology (CST), University Technology Malaysia (UTM) City Campus Kuala Lumpur since 2001. It represents an innovative shift in the field of learning, providing rapid access to specific knowledge and information, and offers online instruction that can be delivered anytime and anywhere through a wide range of electronic learning solutions such as Web-based courseware and online discussion groups. It can be viewed as making learning materials such as presentation slides available on the web. The aim of e-learning, as any other learning approach is to achieve the learning objectives. Until today students in CST used the e-learning technology only for accessing the syllabus and course content, submitting assignments and taking class quizzes. Meanwhile, most of CST instructors had been given several e-learning courses and workshops by Centre of Teaching and Learning (CTL) in University Technology Malaysia regarding course content development. In this connection, the instructor plays a central role in the effectiveness and success of e-learning based courses. This paper will focus on issues relating to the e-learning critical success factors (CSFs) from student perspectives. In this study two main issues related to the e-learning CSFs within a university environment addresses include instructor characteristics and student characteristics.