In this study, thermodynamic modeling and exergoeconomic assessment of a Combined Cycle Power Plant (CCPP) with a Duct Burner (DB) was performed. Obtaining an optimum condition for the performance of a CCPP, using a DB after gas turbine was investigated by various researchers. DB is installed between gas turbine cycle and Rankine cycle of a CCPP to connect the gas turbine outlet to the Heat Recovery Steam Generator (HRSG) in order to produce steam for bottoming cycle. To find the irreversibility effect in each component of the bottoming cycle, a comprehensive parametric study is performed. In this regard, the effect of DB fuel flow rate on cost efficiency and economic of the bottoming cycle are investigated. To obtain a reasonable result, all the design parameters are kept constant while the DB fuel flow rate is varied. The results indicate that by increasing DB fuel flow rate, the investment cost and the efficiency of CCPP are increased. T-S diagram reveals that by using a DB, higher pressures steam in heat recovery steam generator has higher temperature while the low pressure is decreased. In addition, the exergy of flow gases in heat recovery steam generator increases. So, the exergy efficiency of the whole cycle was increased to around 6 percent, while the cost of the plant reduced by one percent.