Chronic Lymphocytic Lymphoma (CLL) may transform into an aggressive high grade variant in approximately 4-6% of cases known as Richter’s Transformation (RT). Cutaneous lymphoma as well as other high-grade lymphomas may be a rare presentation of RT. As minimally invasive cosmetic procedures increase in popularity, we present an important mimicker of cutaneous uptake of the lower face simulating RT in a patient with CLL, after the injection of collagen fillers and botulinum toxin A (Botox) to the lower face. To our knowledge there are no previous studies on this important observation. Reading physicians should be cognisant of this masquerade to prevent misdiagnosis.