This study was carried out to determine the level of selected heavy metals (Cu, Zn, Pb and Cd) in edible tissue in mud crab, genus Scylla collected along Setiu Wetland, Terengganu. In this study, Inductively Coupled Plasma Mass Spectrometry (ICP-MS) was used to determine the concentration of heavy metals in mud crabs after digested in closed Teflon bomb with suprapur nitric acid. The average concentration for Cu, Zn, Pb and Cd were 89 μg/g, 137 μg/g, 0.22 μg/g and 0.25 μg/g dry weights respectively. Zinc, Pb and Cd were well correlated with the mud crab size where the metals concentration increasing with the size. This study also revealed that Cu and Zn concentration in the edible tissues most of the samples were also higher if directly compared to the maximum permitted level, 100 μg/g for Cu and 150 μg/g for Zn set by Malaysia Food Regulation. However, the edible tissues that people consumed do not exceed the Provisional Tolerable Weekly Intake (PTWI) value set by FAO/WHO. As a conclusion, the mud crabs from Setiu wetlands are still safe to be consumed and did not give any adverse health risk effect to local communities.