Background: Psycho-education is an integrated component of nursing; the impact of nursing psychoeducational model has been emphasized by several studies. Aim of this study was to apply psycho-education intervention for psychiatric/mental healthcare team. Design: Aquasi-experimental research design was carried out in this study to fulfill the research aim. Sample: The sample consisted of 30 psychiatric/mental health care teams. Tools: The following two tools were developed by the researchers in order to obtain the necessary data: An interview questionnaire & Participants' knowledge about various topics such as mental health & mental disorders, and stigma of mental health. Results: The current study results revealed that there was significant statistical difference in knowledge about the disease between pre and post intervention related to mental health care in the team, compliance to treatment, and recurrent signs and symptoms, using medications, causes of relapse and readmissions. Conclusion:The current study revealed that there was significant statistical difference between pre and post intervention related to mental health team's knowledge about the disease, treatment compliance, and recurrent signs and symptoms, using medications, causes of relapse and readmissions. Recommendations: Psycho-educational interventions should have far-reaching application for acute and chronic mental illness and other life challenges across levels of public health, social and civic services, and/or educational systems.