Universities have adopted academic entrepreneurship as the strategy to grow and influence economy and society. The study aims to study the role of organizational climate and organizational culture of universities coupled with innovative work behaviour of academics in determining academic entrepreneurship. The study premises that the entrepreneurial climate, entrepreneurial culture and innovative work behaviour in universities will account for academic entrepreneurship. It is proposed that the right combination of these variables will enable universities create an overall university environment to promote academic entrepreneurship. The implications and limitations are presented.