Direct Methanol Fuel Cell (DMFC) has shown a great development to replace fossil fuel as new alternative of power sources. However, there are still many issues need to overcome to achieve the dream of world use no more fossil fuel for power sources. One of the main issues is slow catalytic activity of methanol oxidation reaction in anode DMFC. There are several studies of catalysts for methanol oxidation reaction other than Platinum-Ruthenium (PtRu). Finding the catalyst that is cheaper and high reactivity towards methanol oxidation reaction is recommended. The catalyst synthesized should be tested on durability for a long period of time. The selection of catalyst support also affect in methanol oxidation reaction activity in DMFC. Catalyst support must have characteristics in high surface area, conductivity and strong interaction between support and catalyst to prevent leaching problem during long-term operation in DMFC. Several metal alloys and support catalyst has been review in this paper together with discussion about durability of the catalyst. In addition, the DFT study to find the most stable condition of methanol adsorption to occur is highly encouraged. The determination of mechanism reaction using DFT is important in which different pathways will give different activation energy during methanol oxidation reaction. This short overview presented the current research of new catalysts for methanol oxidation reaction.