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Optimisation of cinnamaldehyde-in-water nanoemulsion formulation using central composite rotatable design
Asmawati M. Sail1, Wan Aida Wan Mustapha2, Ahmad Fuad Shamsuddin3, Ahmad Fuad Shamsuddin4.
Thirteen formulations of cinnamaldehyde/non-ionic surfactant/water system nanoemulsions were prepared using highpressure homogenisation. The result showed that varying the cinnamaldehyde/surfactant ratio had effect significantly
(p<0.05) to mean droplet diameter, polidispersity index, ζ-potential, turbidity and whiteness index, while no significant
effect (p>0.05) to viscosity. The mean droplet diameter ranged from 50.48 to 106.4 nm, polydispersity index from 0.06 to
0.28 and ζ-potential from -4.11 to -6.98 mV. The smallest droplet size was produced using 5% cinnamaldehyde and 5%
Tween 80. Response surface for droplet diameter showed that the higher the cinnamaldehyde and surfactant concentrations,
the larger the droplet diameter, polydispersity index and whiteness index. However, the ζ-potential increased as the
cinnamaldehyde concentration decreased and Tween 80 increased. Increasing the cinnamaldehyde concentration led
to an increase in turbidity. Formulation of 5% cinnamaldehyde and 6.23% Tween 80 gave no observable separation of
the nanoemulsion with minimum droplet size, polidispersity index, viscosity, turbidity, whiteness index and maximum
ζ-potential in modulus. The stability of the optimum formulation was sustained for 10 days upon storage at 4°C. The
values of droplet diameter, PDI and ζ-potential were 55.50 nm, 0.08 and -5.38 mV, respectively.
Affiliation:
- Universiti Kebangsaan Malaysia, Malaysia
- Universiti Kebangsaan Malaysia, Malaysia
- Universiti Kebangsaan Malaysia, Malaysia
- Universiti Kuala Lumpur Royal College of Medicine Perak, Malaysia
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