View Article |
(-)-glaciantarcin, a new dipeptide and some secondary metabolites from the psychrophilic yeast glaciozyma antarctica pi12
Andi R. Rosandy1, Seng, Joe Lim2, Jalifah Latip3, Muntaz A. Bakar4, Rozida M. Khalid5, Munir A. Murad, A6, Yeoh, Chiann Ying7, Cheah, Yoke Kqueen8.
A new dipeptide, (-)-glaciantarcin (1) and three known compounds, cyclo(-Pro-Gly) (2), 1-(2-deoxypentofuranosyl)-5-
methyl-2,4(1H,3H)-pyrimidinedione (3) and vidarabine (Ara-A) (4), were isolated from Glaciozyma antarctica PI12,
a cold-adapted yeast. The chemical structures were elucidated by FT-IR, NMR and mass spectrometry. The cytotoxicity
and antioxidant activities of compounds 1-4 were evaluated by using the MTT bioassay on MCF-7 (human breast cancer
cell line), PC-3 (human prostate cancer cell line) and HEK-293 (normal human embryonic kidney cell line) and DPPH
free radical scavenging activity, respectively. At concentration of 400 µM, all compounds showed the highest activity
on MCF-7, with compound 1 at 65%, compound 2 (70%), compound 3 (66%) and compound 4 (58%) cell viability. All
compounds exhibited weak antioxidant properties. To the best of our knowledge, this is the first report of compounds
1-4 from Glaciozyma antactica.
Affiliation:
- Universiti Kebangsaan Malaysia, Malaysia
- Universiti Kebangsaan Malaysia, Malaysia
- Universiti Kebangsaan Malaysia, Malaysia
- Universiti Kebangsaan Malaysia, Malaysia
- Universiti Kebangsaan Malaysia, Malaysia
- Universiti Kebangsaan Malaysia, Malaysia
- Universiti Putra Malaysia, Malaysia
- Universiti Putra Malaysia, Malaysia
Toggle translation
|
|
Indexation |
Indexed by |
MyJurnal (2021) |
H-Index
|
6 |
Immediacy Index
|
0.000 |
Rank |
0 |
Indexed by |
Web of Science (SCIE - Science Citation Index Expanded) |
Impact Factor
|
JCR (1.009) |
Rank |
Q4 (Multidisciplinary Sciences) |
Additional Information |
JCI (0.15) |
Indexed by |
Scopus 2020 |
Impact Factor
|
CiteScore (1.4) |
Rank |
Q2 (Multidisciplinary) |
Additional Information |
SJR (0.251) |
|
|
|