Dengue fever is a viral infection caused by dengue virus that is transmitted via mosquitoes. Increased mortality from the infection also shows that the threat is real. Definitive treatment such as antiviral therapy has not been established and anti-dengue vaccination development was hampered by unprecedented issues. Therefore, alternative treatments have to be sought out. With the cultural diversity and the availability of various tropical plants and food, people in this region have tried and studied various complementary ailments for the infection. People also are looking towards a prophetic approach in preventing and treating dengue infection. This paper illustrates dengue infection from the epidemiological point of view, the standard therapy and issues pertaining to the infection. This paper also discusses complementary treatments of dengue infection such as Carica papaya leaf, coconut juice, Euphorbia hirta and Psidium guajava leaf. Scientific evidence of the effectiveness of these treatments is explained in detail. This paper also looks at the scientific evidence and literatures by Islamic scholars with regards to the use of prophetic methods in the treatment of dengue infection. Dates were shown to be effective in increasing platelet counts. In conclusion, complementary and prophetic medicine may benefit patients with dengue fever infection as an adjunct therapy.