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Crystal engineering of quercetin by liquid assisted grinding method
Athiyah, Umi1, Kusuma, Putu Andika2, Tutik3, Lestari, Maria L.A.D4, Isadiartuti, Dewi5, Paramita, Diajeng Putri6, Setyawan, Dwi Setyawan7.
Quercetin has been proposed to exhibit numerous pharmacological benefits
yet suffer low bioavailability due to the extremely low solubility. A research to
study the impact of cocrystallization of quercetin with succinic acid on the
solubility and dissolution profile has been performed. Cocrystallization in molar
stoichiometry of 1:1 was carried out via liquid assisted grinding with methanol in
ball milling apparatus. Cocrystal formation was identified by hot stage
microscopy (HSM) at first, then cocrystal phase was characterized using
differential thermal analysis (DTA), powder X-ray diffractometry (PXRD),
scanning electron microscopy (SEM), and fourier-transform infrared (FT-IR)
spectroscopy. Solubility and dissolution test were conducted as well. DTA
thermogram exhibits new endothermic peak at 280.32ï‚°C representing the
melting point of cocrystal phase alongside with endothermic point of pure
compounds. Powder X-ray diffractograms show new diffraction peaks on
behalf of cocrystal formation at 2θ=8.92, 9.88, 13.04, 29.78, 35.21ï‚°. FT-IR
spectroscopy reveals band shifting in –OH group region. On SEM photographs,
one can observe crystal habit of succinic acid being covered by crystal with
different habit. This indicates that quercetin interacts with succinic acid only on
the surfaces and causes imperfect formation of cocrystal phase.
Cocrystallization quercetin improves solubility by 1.62 times higher and
dissolution rate by 1.25 higher than pure quercetin (one-way ANOVA, p < 0.05).
Affiliation:
- Universitas Airlangga, Indonesia
- Universitas Airlangga, Indonesia
- Universitas Airlangga, Indonesia
- Universitas Airlangga, Indonesia
- Universitas Airlangga, Indonesia
- Universitas Airlangga, Indonesia
- Universitas Airlangga, Indonesia
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Indexation |
Indexed by |
MyJurnal (2021) |
H-Index
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6 |
Immediacy Index
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0.000 |
Rank |
0 |
Indexed by |
Scopus 2020 |
Impact Factor
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CiteScore (1.4) |
Rank |
Q3 (Engineering (all)) |
Additional Information |
SJR (0.191) |
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