Mental health outcome among teachers has become an escalating problems in many countries. Mental health now- adays has becoming a public health issue. Teachers were not an exclusion from this issue. Several studies did point out teachers with poor mental health status has become an increasing problems in many countries. A total of 272 teachers from the urban, rural and industrial areas participated in this cross sectional study in the Klang Valley. The objective was to determine the risk factors associated with mental health among primary school teachers. The teachers’ mental and physical health status were measured using questionnaires. Respondents were given a set of questionnaire which consisted 5 parts, namely socio-demographic and background status, occupational information and medical history obtained from the first part of questionnaire. The other part consisted of the General Health Questionnaire, Teachers’ Stress Inventory, Modified Nordic Questionnaire and American Thoracic Society for Adult. There was no difference in the background of the groups of teachers except for the educational level (p<0.05). The urban teachers were more highly qualified than the other 2 groups. The majority of teachers showed good mental health and respiratory health status. Less than 50% of the respondents developed one-year prevalence of low back pain. Respiratory symptoms showed a significant relationship with poor mental health status (OR 8.12, 95% CI 2.80–23.56). Respiratory problems were the significant risk factor for poor mental health status (p<0.001) of teachers in schools.