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Elucidation of antimicrobial activity of non-covalently dispersed carbon nanotubes
Saleemi, M. A1, Hosseini Fouladi, M2, Yong, P. V. C3, Eng Hwa, W4.
Introduction: Microorganisms have begun to develop resistant because of inappropriate and extensive use of antibiotics in a hospital setting. Therefore, it seems to be necessary to find a way to tackle these pathogens by developing a new and effective antimicrobial agents. Carbon nanotubes (CNTs) have attracted growing attention due to their remarkable mechanical strength, electrical properties, and chemical and thermal stability for their potential applications in the field of biomedical as therapeutic and diagnostic nano tools. However, the impact of carbon nanotubes to microbial growth has not been fully investigated. The main aim of this study to investigate the antimicrobial activity of CNT, particularly double-walled and multi-walled nanotubes on representative pathogenic strains such as Gram-positive bacteria Staphylococcus aureus, Gram-negative bacteria Pseudomonas aeruginosa, Klebsiella pneumoniae and fungal strain Candida albicans. The dispersion ability of CNTs (DWCNT and MWCNT) treated with surfactant such as sodium dodecyl-benzenesulfonate (SDBS) and their impact on the microbial growth inhibition were also examined. Methods: A stock concentration of 0.2mg/ml for both double-walled and multi-walled CNT was prepared homogenized by dispersing in surfactant solution by using probe sonication. UV-vis absorbance, Fourier transfer infrared radiation (FTIR) and Scanning electron microscopy (SEM) were used for the characterization of CNTs dispersed in the surfactant solution to study the interaction between molecules of surfactant and CNTs. The antimicrobial activity was determined by analyzing optical density growth curves, viable cell number and zone of inhibition. Results: This study revealed that microbial growth inhibited by non-covalently dispersed MWCNT was both depend on the concentration and treatment time. In conclusion, the binding of surfactant molecules to the surface of CNT increases its ability to disperse in aqueous solution. Non-covalent method of CNTs dispersion preserved their structure and increased microbial growth inhibition as a result. Conclusion: Multi-walled CNT exhibited higher antimicrobial activity compared to double-walled CNT against selected pathogens.
Affiliation:
- Taylor's University, Malaysia
- Taylor's University, Malaysia
- Taylor's University, Malaysia
- Taylor's University, Malaysia
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Indexation |
Indexed by |
MyJurnal (2021) |
H-Index
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3 |
Immediacy Index
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0.000 |
Rank |
0 |
Indexed by |
Scopus 2020 |
Impact Factor
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CiteScore (0.2) |
Rank |
Q4 (Medicine (all)) |
Additional Information |
SJR (0.144) |
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