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Macrophage and dendritic cell biology: implications for disease
Florent Ginhoux1.
Macrophages, monocytes, and dendritic cells play crucial and distinct roles in tissue homeostasis and immunity, but also contribute to a broad spectrum of pathologies and are thus attractive therapeutic targets. Potential intervention strategies aiming at manipulation of these cells will require in-depth insights of their origins and the mechanisms that govern their homeostasis and activation. Our approach encompasses the integration of high dimensional platforms such as RNAseq, single cell transcriptome analysis using microfluidic RNA sequencing and deep immunophenotypic assessment using state of the art 25 parameters flow cytometry or Cytometry by Time-Of-Flight mass spectrometry (CyTOF). Such high density molecular profiling at the single level and at unprecedented dimensionality and com-plexity will provide new insights in the biology of DC, monocyte and macrophage cell populations. Defining macro-phage and DC populations on the criteria of their origin may aid our understanding of their discrete roles in tissue im-munity and homeostasis, as ontogeny of DC and macrophage subsets likely underlie their functional specializations.
Affiliation:
- Agency for Science, Technology and Research (A*STAR), Singapore, Singapore
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Indexation |
Indexed by |
MyJurnal (2021) |
H-Index
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3 |
Immediacy Index
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0.000 |
Rank |
0 |
Indexed by |
Scopus 2020 |
Impact Factor
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CiteScore (0.2) |
Rank |
Q4 (Medicine (all)) |
Additional Information |
SJR (0.144) |
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