Introduction: Ameloblastoma is a locally invasive tumour from odontogenic origin and usually treated by radical approach. The purpose of this study is to describe ameloblastoma profile and management in Dr. Soewandhie Hos-pital and Airlangga University Hospital in 3 years of a retrospective study. Methods: Data from all Ameloblastoma cases between January 2017 until June 2019 were collected from Dr. Soewandhie and Airlangga University Hospital. Information regarding gender, age, tumour location, histopathological examination, and treatment were recorded, reviewed, and analyzed. Results: There are 20 cases of ameloblastoma from January 2017 to June 2019. Males and females ratio are 1:1. There are 5 patients were treated in 2017, 10 patients were treated in 2018, and 5 patients were treated in 2019. Four patients with tumour on the anterior part of the mandible (20%), 7 patients with tumour on the right posterior of the mandible (35%), 6 patients with tumour on the left posterior of the mandible (30%), and 3 patients with tumour in mixed area of the mandible (15%). Nineteen patients were treated radically (95%), and 1 patient (5%) were treated with marsupialization for further follow-up. Conclusion: All tumour presented in this study is located in the mandible. Most ameloblastoma was treated with a radical approach.