Introduction: The traumatic ulcer is a pathological condition that causes damage to the entire epithelial layer and the underlying tissue, coated with fibrin tissue, so it is yellowish-white. In 2009, the prevalence in Indonesia reached 60.5%. Oral ulceration may be the most oral mucosal disease frequently seen and serious. Although many oral ulcers have a similar clinical appearance, the underlying etiological factors can vary from reactive lesions, neoplastic and oral manifestations of skin diseases. Oral ulceration can also be manifestations of epithelial damage for defects. The aim for this reaserach is to prove the effect of patin fish gelatin (Pangasius djambal) on angiogenesis and remodeling by MMP13 in the healing process of traumatic ulcers (in vivo). Methods: This study used an experimental research design purely with Post Test Only Randomized Control Group Design in vivo. We will divide the subject research into 2 groups with time series. This study used 30 mice with 5 samples for each group: untreated mice and treat-ed mice. Results: There is a significant relationship between the group angiogenesis given patin fish gelatin in the wound healing process with a positive correlation which means it influences increasing the number of blood vessels. Conclusions: Administration of patin fish gelatin is the most effective treatment and can speed up increasing the num-ber of blood vessels or angiogenesis which shows an increase in the speed of wound healing in the post-traumatic ulcer. MMP13 also can enhance remodeling cells in wound healing.