Introduction: Tooth extractions can cause tissues damage arround the extraction area and wound healing will occur later. Fibroblasts cell play an important role in repairing of tissues injuries with synthesis component matrix ekstrasel. The lime peel decoction (Citrus aurantiifolia) have highest flavonoid content. Flavonoid has effects inflammatory phase of wound healing process. The purpose of this research is to know the effect of lime peel decoction to number of fibroblasts cells on wound healing after tooth extractions. Methods: This research was conducted with an experi-mental approach laboratoris in in vivo. The research design used Randomized Post Test Only Control Group Design. The total rats were 30, divided into 6 groups, there were the control group was not given the lime peel decoction (K7, K14, K21) and the treatment group was given the lime peel decoction (P7, P14, P21) each sacrificed on the day 7th, 14th, 21st and made the preparations of histology tissue with hematoxylin-eosin staining to count the number of fibroblasts cells. Result: Data were analysed using One-way Anova which is showed a significantly differences be-tween control group and treatment group on the 7th day and there were no differences meaningful between control group and treatment group in day 14th, 21st. Pearson correlation test showed that increasing the day indicates the number of fibroblasts cells progressively decreased. Conclusion: The lime peel decoction has an impact to number of fibroblasts cells on wound healing after tooth extractions.