Introduction: Disruption of ovarian function is frequently correlated by periodontitis, although the correlation is presently unclear. Porphyromonas gingivalis (Pg), as dominant periopathogen, may induce ovarian function disrup-tion, which it later will stimulate a metabolic syndrome in menopause condition related to estrogen hormone status. No study has investigated it yet. This study was aimed to know the metabolic syndrome risk in ovarian dysfunction triggered by Pg. Methods: This study presented in an experimental laboratory study using rats Sprague Dawley Strain. The present study divided the animal models into four groups: control, ovariectomy group (OVX), ovariec-tomy-periodontitis group (OPG), and periodontitis group (PG). All of the treatment groups were performed to get ovarian dysfunction. The blood samplings were observed on 0, 3rd, 7th, 14th, 21st, and 28th days. The blood sampling was analysed the glucose, cholesterol, uric acid, and estrogen. The obtained data were analysed statistically. Re-sults: Most of the treatments groups presented body weight and blood biochemical observation significantly higher than the control group, except in total cholesterol level (p<0.05). The alteration of biochemical parameters related to treatment and estrogen level (R>0.5). Conclusions: The present study revealed that ovarian dysfunction triggered by Pg infection stimulated the metabolic syndrome risk. Beside it, Pg infection could worsen the severity of the met-abolic syndrome. Hence, this study would be the novel paradigm about the role of Pg in ovarian function, while it was required for further studies.