Introduction:Post-tooth extraction makes alveolar bone loss progressive, especially in the first 6 months. Inadequate alveolar bone hampers dental prosthetic, implant reconstruction and esthetic problems. Therefore, alveolar ridge preservation should be performed to avoid aggressive bone loss post-extraction. Poly(lactic-co-glycolic acid) (PLGA) is one polymer which widely used in biomedical. This present study was conducted to evaluate the percentage of biodegradability and the size of pores Hydroxyapatite nanoparticles/PVA composites which was coated PLGA for potential alveolar ridge preservation materials. Methods: There was divided into 2 groups: Hydroxyapatite nanopar-ticles/PVA composites and Hydroxyapatite nanoparticles/PVA/PLGA composites which contained 20% PLGA (w/w). All of composites were prepared by freeze drying methods at -50 oC. Biodegradability rate was evaluated by soaking composites into PBS for 12 weeks at 37 oC, then measured water uptake (%) and water loss (%). The pore size was evaluated by FE-SEM analysis. Statistical analysis based on Independent T-test (p<0.05). Results: The experimental results showed that Hydroxyapatite nanoparticles/PVA/PLGA composites have greatest biodegradable properties and proper pore size and structure for bone regeneration. The water uptake and water loss of Hydroxyapatite nanoparti-cle/PVA/PLGA composite was 819.60% (p<0.05) and 70.74% (p<0.05) which greater than Hydroxyapatite nanopar-ticle/PVA composite (271.25% and 58.38%). Moreover, the pore size of Hydroxyapatite nanoparticle/PVA/PLGA composite was 176 ± 61.93 μm which also greater than Hydroxyapatite nanoparticle/PVA composite (54.53 ± 35.74 μm). Conclusion: Hydroxyapatite nanoparticle/PVA/PLGA composite has excellent biodegradability properties and morphology which would be a promising material for alveolar ridge preservation to achieve bone regeneration.