Introduction: Elderly is something that happens naturally to all people in this world without exception. Physical changes in the elderly cause the elderly to lack confidence in social relations with the community and various diseas-es that can attack the elderly both acute and chronic. The increase in disease disorders causes changes in the quality of life of the elderly. Hygiene of the teeth and mouth needs to be considered and improved because it is something that is integral to overall health. Hygiene of the teeth and mouth can affect the quality of life of the elderly. This study aims to detearmine the relationship of dental and oral hygiene to the quality of life of elderly in the Wredha Pangesti nursing home. Methods: The design in this study was observational analytic with cross sectional approach. The sam-pling technique was purposive sampling. Results: Elderly who have dental and oral hygiene, at most in the criteria of being 21 people (70%) and the elderly who have quality of life, at most in the moderate criteria of 22 people (73.3%). Conclusion: Data analysis using the Pearson Correlation Test and Spearman Correlation Test shows that there is no relationship between dental and oral hygiene to quality of life.