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Wound healing effect of lime peel decoction (Citrus aurantifolia) on the osteoclast number in alveol of wistar rats after tooth extraction
R. Setyohadi1, Irwan Baga2, Azimah Nurin Nafilah3.
Introduction:Tooth extraction causes damage to oral tissue and needs treatment to restore chewing, aesthetics, speech function, and prevent tooth extrusion. Osteoclasts in alveolar play an important role in bone healing, es-pecially in the remodeling phase of bone resorption at the start of new bone formation. Lime peel contains many active compounds such as flavonoids, vitamin C and tannins that possesses antibacterial, anti-inflammatory and antioxidants. Therefore, this study was aimed to determine the effect of lime peel decoction (Citrus aurantifolia) on the number of osteoclast alveoli in Wistar rats after tooth extraction. Methods: Two-month-old male Wistar rats were divided into 6 groups of 5 animals in each group namely: control groups without lime peel decoction (K1, K2, K3) and treatment groups with lime peel decoction (P1, P2, P3). The first mandibule incicivus were extracted and the treatment groups were given 1 cc lime peel decoction once a day for seven days (P1) fourteen days (P2) and twenty first days (P3), then decaputed on the 7th, 14th, 21st day and proceeded to histology tissue preparations to calculate the number of osteoclasts. Results: The lime peel decoction was found to decrease the number of osteoclasts on 14th days along with that osteoblast proliferate so that induce the formation of new bone. Treatment group reached remodelling process on 14th days while the control group estimated on 29th days. One-Way ANOVA showed a significant difference between group K2 and group P2. Conclusion: Based on this study, it can be concluded that the lime peel decoction (Citrus aurantifolia) affects the amount of osteoclast alveolar in Wistar rats after tooth extraction and accelerate healing process.
Affiliation:
- Brawijaya University, Indonesia
- Brawijaya University, Indonesia
- Brawijaya University, Indonesia
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Indexation |
Indexed by |
MyJurnal (2021) |
H-Index
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3 |
Immediacy Index
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0.000 |
Rank |
0 |
Indexed by |
Scopus 2020 |
Impact Factor
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CiteScore (0.2) |
Rank |
Q4 (Medicine (all)) |
Additional Information |
SJR (0.144) |
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