Introduction: Oral health problems, including oral soft tissue lesions, in Indonesia is increasing annually. Motiva-tion in Oral Medicine learning is needed for dentists to treat these issues. This study aims to determine the level of learning motivation in Oral Medicine among dental students of Universitas Indonesia. Methods: This study used an analytic-descriptive study with cross-sectional design by gathering data directly from total population of Universitas Indonesia dental students. Respondent were divided into three groups based on curriculum. Data gathering was using Science Motivation Questionnaire II (SMQ-II), which include five motivation components, consist of intrinsic motivation, self–efficacy, self–determination, grade motivation and career motivation. Results: The response rate of this study was 96.6% (743 respondent). The result of Interclass Correlation Coefficient of 0,941, indicated was a good internal consistency. In discriminant validity test, grade motivation and career motivation of pre-clinical groups showed no significant difference. Among three respondent groups, clinical years acquired the highest mean score for highly motivated groups (mean: 67.27), followed by pre-clinical taken OM (mean: 65.89), ended by pre-clinical hadn’t had OM (mean: 62.54). The highest mean score for overall motivation, acquired by clinical years. Conclu-sion: Clinical years have the highest motivation level to learn in Oral Medicine.