Introduction:Compressive strength is a mechanical property as a posterior tooth restorative to avoid cracking the restoration due to chewing pressure. Compressive strength composite resin has different strengths depending has a different strengths depend on the resin material. One of the applications of dental nanotechnology is nanohybrid resin composite which has compressive strength over microfiller composites. The composition of nanohybrid is nano-sized filler combined with micro-sized filler. Composite resins with a new fillers, which is known as fiber re-inforced composites (FRC), is offer highfracture resistance because they contain E-glass fiber which can increase the hardness of composite resins. The aim of this research is to know the difference of compressive strength between nanohybrid resin composite and fiber reinforced composite. Methods: This study used 20 resin composite samples divided into 2 groups, group A was a nanohybrid resin composite restoration and group B was a fiber reinforced composite restoration, formed to resemble a cylindrical tube with a diameter of 4 mm and a height of 6 mm. Samples were given the same treatment by incremental technique and light cure for 20 seconds in every 2mm layers. After-ward the sample was fed into the incubator at 37 °C for 48 hours. Each sample were tested for compressive strength test by using Universal Testing Machine (UTM) within 1mm/sec speed. Results: The data ware analised by t-test and showed a significanly difference (p>0,05). Conclusion: This study revelaed that the strenght of fiber reinforced com-posite was greater than greater than nanohybrid resin composite.