Introduction: The purpose of this study was to determine the effectiveness of brushing teeth with the dry compared to wet technique, using a toothpaste containing 1.5% vegetable enzymes. Methods: Pre-post test studies was per-formed with the randomly-selected sampling technique. Samples were divided into two groups, namely, Group 1: Teeth brushing with dry technique, Group 2: Teeth brushing with wet technique. Participants in both groups were instructed to brush with the roll method and use toothpaste containing 1.5% enzymes, and the plaque was then ex-amined by the Patient Hygiene Performance (PHP) Index to score the plaque especially in the aproximal region. The scoring of the plaque was 0 = No plaque; and 1 = plaque (debris). Samples from the dry and wet technique brushing were examined for PHP index after 4 hours. Data was analyzed by parametric statistical and T-test. Results: There is a significant difference between dry and wet brushing technique as determined by paired t-test (p = 0.001). The dry teeth brushing scores recorded a PHP Index lower than the wet teeth brushing technique. Conclusion: Dry teeth brushing technique using a toothpaste that contains 1.5% enzymes is effective for prevention of plaque teeth.