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Administration of Graptophyllum pictum leaves extract in wound healing process on collagen density
Intan Nirwana1, Muhammad Ramadhan Brahmantyo2, Devi Rianti3.
Introduction: An incision in the oral cavity is made for gingivectomy. The benefit of using Graptophyllum pictum leaves extract as an alternative herbal medicine is that it has fewer side effects. Graptophyllum pictum extract con-tains active substances such as flavonoids, saponins, and tannins. These compounds have anti-inflammatory and antioxidant activities and play a role in wound healing processes. An important marker of wound healing is collagen density. Increased collagen synthesis during the proliferative phase of cells accelerates the wound healing process. This study observed the collagen density in wound healing process of Wistar rats’ wound after administration of Graptophyllum pictum leaves extract. Methods: The study was conducted by making incision wounds in 24 Wistar rats which were divided into control groups and treatment groups. The control groups were left untreated and the treatment groups were given Graptophyllum pictum extract on the incision wound once every day for three, seven and fourteen days, and then the animals were sacrificed. Wound tissue was removed and fixed in 10% formalin solution, embedded in paraffin, and stained with Masson’s Trichome (MT) to observe the density of collagen micro-scopically. Statistical analyses of collagen density were performed using Kruskall Wallis and Mann Whitney tests. Results: There were significant differences among the groups (p<0.005) on the collagen density after treatment for three, seven and fourteen days. Conclusion: Administration of Graptophyllum pictum leaves extract on Wistar rats’ wound could increase the collagen density in the wound healing process.
Affiliation:
- Universitas Airlangga, Indonesia
- Universitas Airlangga, Indonesia
- Universitas Airlangga, Indonesia
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Indexation |
Indexed by |
MyJurnal (2021) |
H-Index
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3 |
Immediacy Index
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0.000 |
Rank |
0 |
Indexed by |
Scopus 2020 |
Impact Factor
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CiteScore (0.2) |
Rank |
Q4 (Medicine (all)) |
Additional Information |
SJR (0.144) |
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