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Body mass index (BMI) and the secretion of salivary human β defensins 1 (HBD-1): a study in children with dental caries
Nuraini Indrastie1, Retno Indrawati2, Muhammad Luthfi3, Hendrik Setia Budi4, Dien Nisa Aulia5, Tamimma Izzat Nabella6.
Introduction: Human beta defensins 1 (hBD-1) is a peptide with antimicrobial activity. Sensitive to both gram nega-tive and gram positive bacteria, hBD-1 is produced by epithelial tissues and produced continuously in many organs, including in the oral cavity. Recently, hBD-1 has been detected in saliva and is linked to oral disease. Alongside other human beta defensins, the role of hBD-1 is important in innate immune responses. Physical condition also plays an important role in innate immune responses, including body mass index (BMI). The aim of this study was to find the relationship between BMI and the secretion of salivary hBD-1 in children with dental caries. Methods: This study obtained ethical approval from the local ethics committee. Children aged 9-10 years (n=40) with dental caries were included in this study. The weight (in kgs) and height (in cms) were measured and the BMI was calculated using BMI formula measurement for children. The children were divided into two groups (BMI>17 and 17<BMI). The oral examination was done using DMF-T and def-t index. Unstimulated saliva samples were collected and the secretion of hBD-1 were determined by ELISA (in μg/ml). Results: Statistical analysis showed that there was no correlation between BMI and the secretion of salivary hBD-1 (p>0.05; p=0.385). Further statistical analysis between low BMI (BMI<17) and the secretion of salivary hBD-1 also showed no correlation (p>0.05; p=0.788). No correlation was shown between high BMI (BMI>17) and the secretion of salivary hBD-1 (p>0.05; p=0.865. Conclusion: From this study, it can be concluded that the secretion of salivary hBD-1 in children with dental caries varies among individ-uals.
Affiliation:
- Universitas Airlangga, Indonesia
- Universitas Airlangga, Indonesia
- Universitas Airlangga, Indonesia
- Universitas Airlangga, Indonesia
- Universitas Airlangga, Indonesia
- Universitas Airlangga, Indonesia
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Indexation |
Indexed by |
MyJurnal (2021) |
H-Index
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3 |
Immediacy Index
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0.000 |
Rank |
0 |
Indexed by |
Scopus 2020 |
Impact Factor
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CiteScore (0.2) |
Rank |
Q4 (Medicine (all)) |
Additional Information |
SJR (0.144) |
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