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Level of interleukin-1β and interleukin-6 in pregnant women with dental caries
Retno Indrawati Roestamadji1, Udijanto Tedjosasongko2, Mega Moerhaeyono3, Jayanthi Dira Andini4.
Introduction: Pregnancy is a physiological process that causes changes in the body, one of which is hormonal changes that cause microbiomes in the oral cavity of the mother to experience dysbiosis. This makes pregnant wom-en more susceptible to dental caries affect IL-1β and the IL-6 response serves as a marker of inflammation. IL-1β and IL-6 will increase if there are active caries, and periapical lesions. Pregnant women will transfer microbiomes to the baby during vaginal delivery or cesarean section, therefore the mother’s microbiome during pregnancy will be the same as the baby. The purpose of this study was to analyze the levels of IL-1β, IL-6 and oral microbiome in preg-nant women with or without dental caries. Methods: A cross-sectional study of 20 pregnant women at Bhayangkara Hospital Surabaya by screening for dental caries and a questionnaire to support the data, after which saliva samples were collected. Saliva was then tested by ELISA for IL-1β and IL-6 levels and 16sRNA PCR. Results: The results of the study with the Kruskal-Wallis test obtained p = 1.00 (p> 0.05) for the IL-1β correlation between pregnant women with or without dental caries. As for the IL-6 correlation between pregnant women with or without dental caries, p = 0.998 (p> 0.05). PCR 16 sRNA results showed differences in oral microbiome variations in groups of pregnant wom-en with or without dental caries (correlation of microbiome of maternal and infant oral cavities was not included). Conclusion: From the results of this study there was no increase in IL-1β and IL-6 in pregnant women with or without dental caries.
Affiliation:
- Universitas Airlangga, Indonesia
- Universitas Airlangga, Indonesia
- Universitas Airlangga, Indonesia
- Universitas Airlangga, Indonesia
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Indexation |
Indexed by |
MyJurnal (2021) |
H-Index
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3 |
Immediacy Index
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0.000 |
Rank |
0 |
Indexed by |
Scopus 2020 |
Impact Factor
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CiteScore (0.2) |
Rank |
Q4 (Medicine (all)) |
Additional Information |
SJR (0.144) |
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