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The effect of brotowali (Tinospora crispa) extract on number of macrophage cell of Wistar rats (Rattus norvegicus) periodontitis
Tuti Kusumaningsih1, Ira Arundina2, Tantiana3, Rini Devijanti R4, Indeswati Diyatri5, Poppy Raissa Hudayanti6.
Introduction: Periodontitis is an inflammatory disease of the periodontal tissues commonly caused by the bacteria Actinobacillus actinomycetemcomitans. In the healing process of periodontitis, macrophages have an important role in the inflammatory phase. Brotowali (Tinospora crispa) contains flavonoids that can accelerate the healing of peri-odontitis. Methods: Brotowali extract was taken from brotowali dried stems. The dried specimens were processed into powder and macerated with 80% ethanol. The extraction was prepared in three concentrations, namely, 25, 50 and 100%. Wistar rats were divided into 5 groups, the negative control group: healthy Wistar rats; the positive control group: Wistar rats with periodontitis; treatment group 1 = Wistar rats with periodontitis given brotowali ex-tract concentration of 25% (dose 0.1 ml); treatment group 2 = Wistar rats with periodontitis given brotowali extract concentration of 50% (dose 0.1 ml); Group 3 = Wistar rats with periodontitis given brotowali extract concentration of 100% (dose 0.1 ml). Histological slides were prepared to calculate the number of macrophages. Results: One-Way ANOVA test showed significant differences in each group. Test Tukey HSD Post Hoc Test showed no significant difference between group 1 and group 2. Conclusion: Brotowali extract may affect the number of macrophage cells of Wistar rats induced by bacteria Actinobacillus actinomycetemcomitans.
Affiliation:
- Universitas Airlangga, Indonesia
- Universitas Airlangga, Indonesia
- Universitas Airlangga, Indonesia
- Universitas Airlangga, Indonesia
- Universitas Airlangga, Indonesia
- Universitas Airlangga, Indonesia
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Indexation |
Indexed by |
MyJurnal (2021) |
H-Index
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3 |
Immediacy Index
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0.000 |
Rank |
0 |
Indexed by |
Scopus 2020 |
Impact Factor
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CiteScore (0.2) |
Rank |
Q4 (Medicine (all)) |
Additional Information |
SJR (0.144) |
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