Innovative work behavior has gained considerable attention in the organisational behavior literature. Research on an integrated framework that cover personal predictors of innovative work behavior is still limited specifically among Malaysia government school teachers. This research incorporated the components of an individual’s behavioral (behavior-focused), cognitive (constructive thought pattern and natural reward) and physiological (physical vitality) approach asself-leadership strategiesthatserve as predictors of innovative work behavior. This research used Revised Self-Leadership Questionnaires (RSLQ) to measure teacher’s self-leadership strategies and Innovative Behavior Scale by Robert and Christopher (2001) was used to measure individual’s innovative behavior. This research utilized quantitative approach where questionnaires were distributed to 250 government school teachers as a sample of the research. Overall, 234 completed questionnaires were usable for data analysis. The data was analyzed by using IBM Statistical Package for Social Science 22 statistical. The findings indicated that behavior-focused strategies, constructive thought pattern strategies, natural reward strategies and physiological strategies significantly affected innovative work behavior of government school teachers. The findings of the study may help organizations to increase teachers’ innovative work behavior by improving teachers’ self-leadership strategies at the workplace.