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Physical characterisation of electrospun PVDF/PVA nanofibre membrane as a potential artificial soft tissue scaffold application
Mohd Syahir Anwar Hamzah1, Celine Ng2, Ashari Kasmin3, Latifah Md Ariffin4, Saiful Izwan Abd Razak5, Nadirul Hasraf Mat Nayan6.
The application of nanofibrous scaffold in tissue engineering has great potential in solving
the drawbacks of conventional tissue/organ transplant procedures. This present work aims
to evaluate the effect of polyvinyl alcohol (PVA) inclusion on the physical properties of
polyvinylidene fluoride (PVDF) nanofibrous membrane fabricated via the electrospinning
method and its potential as an artificial tissue scaffold. The physical performance of
electrospun PVDF/PVA samples was assessed by field emission scanning electron microscope
(FESEM), tensile strength, water contact angle (WCA), degree of swelling, conductivity level,
and Fourier transform infrared (FTIR) spectroscopy. Based on the physical
characterisations, sample 90PVDF/10PVA with the PVDF-to-PVA ratio of 90:10 was the
optimum composition, where the electrospun samples exhibit the most balanced properties
that meet the requirement for artificial soft tissue replacement. In vitro studies using human
dermal fibroblast (HDF) cells show that the PVDF/PVA nanofibrous scaffold successfully
enhanced the adhesion and proliferation of cells compared to the neat PVDF scaffold as
indicated by the MTT assay and Live/Dead kit. Overall results show the potential of
PVDF/PVA nanofibrous membrane as a promising material suitable for soft tissue
engineering applications
Affiliation:
- Universiti Tun Hussein Onn Malaysia, Malaysia
- Universiti Tun Hussein Onn Malaysia, Malaysia
- Universiti Tun Hussein Onn Malaysia, Malaysia
- Universiti Tun Hussein Onn Malaysia, Malaysia
- Universiti Teknologi Malaysia, Malaysia
- Universiti Tun Hussein Onn Malaysia, Malaysia
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Indexation |
Indexed by |
MyJurnal (2021) |
H-Index
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2 |
Immediacy Index
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0.000 |
Rank |
0 |
Indexed by |
Scopus 2020 |
Impact Factor
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CiteScore (1.3) |
Rank |
Q3 (Electrical and Electronic Engineering)) Q4 (Electronic, Optical and Magnetic Materials) |
Additional Information |
SJR (0.298) |
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