The turn of the 21st century witnessed an unprecedented surge in the use of Social Network Sites (SNSs). The developing world also experienced a similar congruent networking transformation in terms of employment of the emerging SNN tools. Correspondingly, research magnitude on the implication of SNSs use has also grown exponentially with recommendations for conducting studies in less privileged countries. The present systematic review is based on doctoral research aimed to present the status of SNSs studies and psychological well-being in both developing and developed countries. The review analyzed thirty-two articles–published during 2005 to 2018 and focused on the relationship between SNSs usage and users’ psychological well-being. The results revealed that higher number of academic research regarding social media use and psychological wellbeing was conducted in developed part of the world, mainly in USA Given the limitations of the available literature, the review also recommended suggestions for future directions in investigations and studies on the subject