Typical reactions for infertile males that include loss of self-esteem, self-confidence, and frustration as well as shock, grief, depression and anger and a sense of control over one's destiny. Aim: This study was aimed to assess socio-demographic characteristics and self-esteem and determine relationship between clinical, sociodemographic characteristics and self-esteem of infertile males. Design: A descriptive correlational design was utilized in this study. Apurposive sample of 150 subjects with100 was studied group and 50 was control group. Settings:The study was conducted at the outpatient clinic of andrology and STDs in Assiut University Hospital. Tool for data collection consisted of three parts: 1-Demographic and clinical data sheet 2- Socioeconomic status data scale, 3- Modified form of Rosenberg Self-Esteem Scale (RSES). Results: The study results revealed that. The most of fertile and infertile age groups was from 28 to <38 years old. 65% of infertile males and 58% of fertile males were from rural area. About 63% of infertile males were primary infertility. As well as 56% of infertile males were 1-3 years. About 74% of infertile males were smoked. There was highly statistically significant difference between level of self-esteem among infertile and fertile males (p=0.000**). Conclusion: The study concluded that, infertile males were having low self-esteem more than fertile males. There were no statistically significant differences between self-esteem and levels of socio-economic status related to infertile males. Recommendations: A psychosocial counseling program should be provided for infertile males to improve their self-esteem and help them cope successfully.