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Location and Size are Useful Features in Diagnosing Sessile Serrated Adenoma/Polyp
Shahril Fikri Zul Hasnan Najib1, Noor Afidah Mohamed Shabery2, Huzlinda Hussin3.
Introduction: According to the predefined 2010 World Health Organisation criteria, serrated colonic polyps (SCP)
are pathologically classified into hyperplastic polyp (HP), sessile serrated adenoma/polyp (SSA/P) with or without
cytological dysplasia and traditional serrated adenoma (TSA). Sessile serrated adenoma/polyp is acknowledged as
a precursor of colorectal carcinoma through the serrated neoplastic pathway. Hyperplastic polyps display similar
histological features to SSA/P, in comparison to other types of SCP. It is noteworthy to discriminate between HP and
SSA/P, since only the latter has a malignant potential. Method: A total of 198 cases of SCP were identified and the
slides were reexamined and reclassified accordingly. Analysis on the proportion of SSA/P among SCP and underdiagnosed cases of SSA/P was performed. The association between SSA/P and non-SSA/P with demographic data and
colonoscopic findings were also studied. Results: From the 198 cases of SCP, 164, 29 and five cases were reclassified
as HP, SSA/P and TSA respectively. Sixteen cases of SSA/P were underdiagnosed as HP. From among 29 cases of
SSA/P, the majority were ≥ 65 years old (17; 58.6%), male (21; 72.4 %) and Chinese (17; 58.6%). Most of the SSA/P
(16; 55.2 %) were located in the right colon and measured ≥ 10mm (9; 31%) in size. Location (p=0.004) and size
(p=0.013) of the colonoscopic findings were significantly associated with SSA/P. Conclusion: Underdiagnosed cases
of SSA/P among HP were identified most likely because of the resemblance of their histological features. The location
and size of SCP may suggest the probability of SSA/P.
Affiliation:
- Universiti Putra Malaysia 43400 Serdang, Selangor, Malaysia, Malaysia
- Hospital Selayang, Malaysia
- Universiti Putra Malaysia 43400 Serdang, Selangor, Malaysia., Malaysia
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Indexation |
Indexed by |
MyJurnal (2021) |
H-Index
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3 |
Immediacy Index
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0.000 |
Rank |
0 |
Indexed by |
Scopus 2020 |
Impact Factor
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CiteScore (0.2) |
Rank |
Q4 (Medicine (all)) |
Additional Information |
SJR (0.144) |
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