Introduction: Improved energy balance, metabolic status, and natural antibodies (NAb) has been shown in cows with no dry period, however these cows showed increased inflammation status in early lactation. The aim of this study was to determine the association between plasma natural antibodies and inflammatory biomarkers in cows with no dry period during the first two weeks postpartum. Methods: Holstein-Friesian dairy cows (n=55) were selected. Before enroll to the experiment, cows were clinically healthy. Plasma samples were collected at week 1 and 2 after calving and were analyzed for NAb binding megantura-keyhole limpet hemocyanin and inflammatory biomarkers. Results: Cows with no dry period in this study had an improved energy balance and maintain NAb titers but increased ceruloplasmin (inflammatory biomarkers) in early lactation. In this study we found a significant correlation between NAb IgG binding KLH and haptoglobin in plasma (P<0.01). However, there were no correlations between albumin, cholesterol and NAb (IgG and IgM) binding KLH. Conclusion: This study demonstrate that cows with no dry period have an improved energy balance and maintained the level of natural antibodies in plasma. Moreover, IgG titers in plasma might be correlated with haptoglobin due to inflammation during calving until 2 wk postpartum.