Introduction: Colorectal cancer is a disease that occurs from three major pathways: sporadic, hereditary, and inflammatory. Carica pubescens (CP) have potential chemopreventive effects. This study wants to determine the effect of CP leaf extract on the neutrophil-lymphocyte ratio (NLR), erythrocyte count, and colon histopathological appearance of rats induced by dimethylhydrazine (DMH). Methods: The samples were Sprague Dawley rats (n=35, male, 5-7 weeks aged, 150-200 grams). NC was the normal control group. The DMH group was induced by 20 mg/kg BW of DMH (subcutaneously) once a week for 15 weeks. CP75, CP150, and CP300 were induced by DMH and given CP leaf extract orally at doses of 75, 150, and 300 mg/kg BW, once daily for 15 weeks. The neutrophil, lymphocyte, and erythrocyte count were measured using hematology analyzer. The histopathological appearance shows the percentage of total aberrant crypt foci, and the degrees of inflammation cells. Results: The NLR of CP75 (0,23±0,042), CP150 (0,26±0,018), and CP300 (0,21±0,039) was significantly lower than DMH (0,64±0,239), p<0,001. The erythrocyte count of CP150 (8,89±1,082 x106 cell/μL; p=0,034) and CP300 (9,24±0,396 x106 cell/μL; p=0,006) was significantly higher than DMH (7,87±0,641 x106 cell/μL). The percentage of total aberrant crypt foci of CP75 (15,71±5,345%,p=0,006), CP150 (18,57±6,901%,p=0,014), and CP300 (5,71±5,345%,p=0,001) was significantly lower than DMH (59,29±32,714%). Conclusion: Carica pubescens leaf extract may reduce the neutrophil-lymphocyte ratio, percentage of total aberrant crypt foci and inflammation degree in colon histopathological appearance, otherwise increase the number of erythrocyte in DMH-induced colon cancer rats.