Introduction: Dyslipidemia and hyperglycemia can cause damage to the body, such as liver damage. Curcumin in turmeric is known to have potential anti-hypercholesterolemia and hepatoprotective effects. The aim of this study was to determine the effect of turmeric extract and powder on liver histopathological appearance, total cholesterol, and triglyceride in alloxan-induced Wistar rats. Methods: An experimental study using twenty male Wistar rats, divided into 4 groups. C1 was the normal control group, C2 was induced by intraperitoneal injection of alloxan with a single dose (160 mg/kg BB). T1 and T2 were induced by alloxan and orally administered by turmeric extract and powder (200mg/kg BW) for 21 days. The indicator of the examination was the percentage of liver damage from histopathological assessment and the lipid profile levels. Results: The steatosis, ballooning degeneration, inflammation degree, and NASH category result of C2 and T2 showed significant differences (p<0,05). The result of C2 and T1 in steatosis, inflammation degree, and NASH category showed a significant difference (p<0,05), but in ballooning degeneration, there was no difference. The cholesterol level on C2 (78,7±4,73mg/dL) was significantly higher than T2 (57,8±11,24 mg/dL; p=0,028) and T1 (55,6±5,98 mg/dL; p=0,009). Triglyceride level on C2 (134,6±36,49 mg/dL) was significantly higher than T2 (60,78±14,34 mg/dL; p=0,028) and T1 (103,1±54,77 mg/dL; p=0,716). Conclusion: Turmeric extract and powder has an effect in decreasing the level of total cholesterol, serum triglyceride, and can reduce the liver damage in histopathology appearance of Alloxan induced Wistar rats.