Introduction: Diabetes mellitus and dyslipidemia is the most common risk factors for stroke and are associated with atherosclerosis, which promote the incidence of stroke. The pulsatility index (PI) by transcranial color-coded duplex ultrasonography (TCCD) evaluates the vascular resistance of the distal of cerebral artery and can predict the cerebrovascular disease like stroke. The aim of the study is to correlate blood glucose and LDL level with PI of cerebral arteries evaluated by TCCD. Methods: The cross sectional study design was performed in 48 patients from January-December 2018 who performed TCCD and were tested for blood glucose and LDL level. Saphiro-Wilk test was performed to analyze the normality of the data then Spearman’s rank correlation test was used to evaluate the correlation of the variables. Results: There were significant correlation of blood glucose and LDL level with PI of cerebral arteries (all p < 0.05). Conclusion: Blood glucose and LDL level are correlated with the PI of cerebral arteries.