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PHYSICOCHEMICAL CHARACTERIZATION OF QUERCETIN-LOADED LIPOSOMES PREPARED BY SONICATION FOR FUNCTIONAL FOOD APPLICATION
NUR AMALINA RAMLI1, NORA’AINI ALI2, SOFIAH HAMZAH3.
This research was intended to synthesize liposome as a nanocarrier to encapsulate quercetin, which is prone to degradation and susceptible to low bioavailability upon oral administration. The liposomes were synthesized by thin-film hydration method and followed by probe sonication for downsizing. Soy phosphatidylcholine (SPC) and cholesterol (CHOL) were employed as the composition of the phospholipid bilayer. Results indicated a dependence of sonication amplitude and time in the formation of free liposomes (FL). The average size of quercetin-loaded liposomes (QL) prepared was 346.4 nm with a narrow polydispersity index (0.22) and a high magnitude of zeta potential (-49.6 mV). These characterizations depict that a homogenous nanovesicle suspension with high stability was successfully synthesized. Quercetin was incorporated into the liposomes with a high encapsulation efficiency of 90.7% and loading capacity of 9.3%. This viable nanocarrier perhaps will provide ingenious protection for a wider spectrum of active agents in food and biopharmaceutical products.
Affiliation:
- Universiti Malaysia Terengganu, Malaysia
- Universiti Malaysia Terengganu, Malaysia
- Universiti Malaysia Terengganu, Malaysia
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Indexation |
Indexed by |
MyJurnal (2021) |
H-Index
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4 |
Immediacy Index
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0.000 |
Rank |
0 |
Indexed by |
Scopus 2020 |
Impact Factor
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CiteScore (0.9) |
Rank |
Q3 (Geography, Planning and Development) Q4 (Pollution) Q4 (Management, Monitoring, Policy and Law) |
Additional Information |
SJR (0.175) |
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