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Smoking as a risk factor for rs10490924 variant age-related macular degeneration in Yogyakarta, Indonesia
Supanji1, Ayudha Bahana Ilham Perdamaian2, Reza Aulia3, Ruri Karina Adelia4, Mohammad Eko Prayogo5, Tri Wahyu Widayanti6, Firman Setya Wardhana7, Muhammad Bayu Sasongko8, Angela Nurini Agni9.
Introduction: The aim of this study was to investigate whether smoking status is a risk factor for age-related mac- ular degeneration (AMD) with rs10490924 variant in Yogyakarta, Indonesia. Methods: A case–control study was conducted using 119 patients with AMD and 100 non-AMD. Whole DNA of all patients was extracted using a commercially available whole blood DNA isolation kit. Polymorphism in the ARMS2/HTRA1 gene was genotyped using a restriction enzyme for rs10490924 (G>T). Details regarding the smoking status of the AMD and the non-AMD population were collected using a questionnaire. Logistic regression analysis was used to confirm the correlation between ARMS2/HTRA1 allele and smoking status. Results: Genotyping results showed that the mean frequency of rs10490924 variant was higher in patients with AMD than in non-AMD patients. There was no statistical difference in smoking status between the AMD and the non-AMD patients. However, smoking increase patients risk of having AMD after adjusted to rs10490924 but cannot stated as cofounder factor. Patients with risk allele have six times possibility of having AMD than non-smoking controls. Conclusion: Smoking status increases the risk for AMD in rs10490924 variant of the ARMS2/HTRA1 gene.
Affiliation:
- Universitas Gadjah Mada, Indonesia
- Universitas Gadjah Mada, Indonesia
- Universitas Gadjah Mada, Indonesia
- Universitas Gadjah Mada, Indonesia
- Universitas Gadjah Mada, Indonesia
- Universitas Gadjah Mada, Indonesia
- Universitas Gadjah Mada, Indonesia
- Universitas Gadjah Mada, Indonesia
- Universitas Gadjah Mada, Indonesia
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Indexation |
Indexed by |
MyJurnal (2021) |
H-Index
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3 |
Immediacy Index
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0.000 |
Rank |
0 |
Indexed by |
Scopus 2020 |
Impact Factor
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CiteScore (0.2) |
Rank |
Q4 (Medicine (all)) |
Additional Information |
SJR (0.144) |
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