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Higher circulating white blood cell and lymphocyte counts in obese metabolic syndrome patients: a preliminary population- based study in Yogyakarta, Indonesia
Anggelia Puspasari1, Citra Maharani2, Rosdiana Mus3, Pramudji Hastuti4, Ika Setyawati5.
Introduction: Tissue and systemic chronic low-grade inflammation are associated with obesity and Metabolic Syn- drome (MetS). Previous studies found that elevated levels of circulating white blood cells (WBC) are associated with the inflammation that occurs in obesity and MetS. Research shows we can prevent chronic disease progression by controlling obesity and reducing inflammation. However, the results were inconsistent between populations. This study aimed to investigate the association of WBC, lymphocytes, and the neutrophil to lymphocyte ratio (NLR) with MetS modified by the presence of obesity. Methods: This research was a cross-sectional study of 202 subjects that included 86 subjects who suffered from MetS. Diagnoses of MetS were based on the NCEP-ATP III modification for Asian populations. Results: This study found increased levels of circulating WBCs and higher NLRs in the MetS group compared to the nonMetS group, but it was not statistically significant. Among patients grouped as MetS and nonMetS based on the presence of obesity, there were statistically significant increased WBC and lymphocyte counts in the MetS-obese group compared to the MetS-non-obese group (p=0.013; p=0.049), and in the MetS-obese group compared to the Non-MetS-non-obese group (p=0.028; p=0.040), respectively. Additionally, circulating lym- phocytes and WBC counts showed positive correlations with excess adiposity and increased cardiometabolic risk. Conclusions: Our results indicated circulating WBC and lymphocytes were associated with MetS in the presence of obesity. These findings may contribute to the strengthening of the clinical evidence that demonstrates controlling obesity can reduce inflammation and prevent chronic disease progression in patients with MetS.
Affiliation:
- Universitas Gadjah Mada, Indonesia
- Universitas Gadjah Mada, Indonesia
- Universitas Gadjah Mada, Indonesia
- Universitas Gadjah Mada, Indonesia
- Universitas Muhammadiyah Yogyakarta, Indonesia
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Indexation |
Indexed by |
MyJurnal (2021) |
H-Index
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3 |
Immediacy Index
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0.000 |
Rank |
0 |
Indexed by |
Scopus 2020 |
Impact Factor
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CiteScore (0.2) |
Rank |
Q4 (Medicine (all)) |
Additional Information |
SJR (0.144) |
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