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Effect of chemotherapy on gingival crevicular alkaline phosphatase level in patients with breast cancer
Nur Rahman Ahmad Seno Aji1, Ahmad Syaify2, Kwartarini Murdiastuti3, Kartika Widayati4.
Introduction: Chemotherapy is one of the modalities for treating breast cancer. Chemotherapy is conducted by administering cytostatic drugs to intervene in the genetic and cellular division of cancer cells. In vitro studies show that exposing osteoblasts to chemotherapeutic agents results in impaired function and activity as indicated by de- creased alkaline phosphatase (ALP) activity. Gingival crevicular fluid (GCF) is considered a biomarker of the oral cavity and can be used to detect cellular events in periodontal pockets. The aim of this study was to determine the effect of chemotherapy on ALP activity in gingival crevicular fluid. Methods: Patients diagnosed with breast cancer at the “Tulip” Integrated Cancer Installation of Dr. Sardjito General Hospital who were scheduled to undergo che- motherapy were recruited as research subjects. Gingival crevicular fluid was taken from the maxillary anterior teeth before the subjects underwent chemotherapy and 7 days after chemotherapy. The ALP assay of gingival crevicular fluid was conducted with an ALP Kit (DiaSys) and absorbance was determined using a UV-Vis spectrophotometer at a wavelength of 405 nm. Data were analyzed by the paired t-test. Results: The results showed significant differences (p < 0.05) before and after chemotherapy. Conclusion: Chemotherapy could affect gingival crevicular ALP activity in patients with breast cancer at the “Tulip” Integrated Cancer Installation of Dr. Sardjito General Hospital.
Affiliation:
- Universitas Gadjah Mada, Indonesia
- Universitas Gadjah Mada, Indonesia
- Universitas Gadjah Mada, Indonesia
- Universitas Gadjah Mada, Indonesia
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Indexation |
Indexed by |
MyJurnal (2021) |
H-Index
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3 |
Immediacy Index
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0.000 |
Rank |
0 |
Indexed by |
Scopus 2020 |
Impact Factor
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CiteScore (0.2) |
Rank |
Q4 (Medicine (all)) |
Additional Information |
SJR (0.144) |
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