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Osteocalcin level of freeze-dried collagen-activated platelet- rich plasma and demineralized freeze-dried bone allograft
Diana Anggraini1, Fitri Yuniawati2, Kwartarini Murdiastuti3.
Introduction: The aim of this preliminary study was to examine the difference between intrabony defects treated by freeze-dried platelet-rich plasma activated by collagen (FD PRP + C) and Demineralized Freeze-Dried Bone Allograft (DFDBA). The parameter used in this study was the osteocalcin level as one of the bone markers indicating osteoblast behaviour in periodontal bone healing. Methods: Gingival Crevicular Fluid (GCF) was harvested using paper point #15 before the surgical procedure at six observational points. Open Flap Debridement (OFD) was performed with graft materials, maxillary anterior teeth with FD PRP + C, and mandibular anterior teeth with DFDBA. GCF was then harvested again from the same points 7 and 14 days after OFD. Osteocalcin was measured by ELISA using a Human Osteocalcin ELISA Kit. Data were then analysed by using an independent Student’s t-test and repeated-measures ANOVA. Results: There was a significant difference in the osteocalcin level between the DFDBA and FD PRP + C groups (p < 0.05). The DFDBA group has a higher Osteocalcin level than the FD PRP + C group. Conclusion: This preliminary study showed that FD PRP + C used in the OFD procedure has lower early bone regeneration compared with DFDBA.
Affiliation:
- Universitas Gadjah Mada, Indonesia
- Universitas Gadjah Mada, Indonesia
- Universitas Gadjah Mada, Indonesia
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Indexation |
Indexed by |
MyJurnal (2021) |
H-Index
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3 |
Immediacy Index
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0.000 |
Rank |
0 |
Indexed by |
Scopus 2020 |
Impact Factor
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CiteScore (0.2) |
Rank |
Q4 (Medicine (all)) |
Additional Information |
SJR (0.144) |
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