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The osteopontin levels between activated collagen - platelet- rich plasma and platelet-rich plasma gel on flap surgery
Kwartarini Murdiastuti1, Fransisca Karyanto2.
Introduction: Platelet-Rich Plasma (PRP) is an autologous blood (platelet concentrates) that able to modulate wound healing in periodontal diseases. Increasing of growth factor number and effectiveness in PRP need activator. Acti- vator PRP that safe and widely used is collagen and CaCl2 (gel). Osteopontin (OPN) is produced by osteoblasts that can stimulate bone remodeling and be found in gingival crevicular fluid (GCF). The research aim was to determine the difference of OPN level in GCF between PRP- collagen and PRP gel on flap surgical therapy. Methods: Samples were taken from the GCF on 20 points of infrabony pockets were divided into 2 groups. Open flap debridement (OFD) was used and combined with PRP-collagen for the first group and for the second group was OFD+PRP gel, which examined on the day, 14, and 21 by measured GCF OPN level used Human OPN Elisa Kit. The collected data were analyzed by Friedman and Wilcoxon test. Results: This study indicated that there was increasing of OPN level in both groups on the day, day14, and day 21 but no significant differences between both groups on day14 and day
21. Conclusion: There was no difference of OPN level in GCF between PRP-collagen and PRP gel on flap surgical therapy.
Affiliation:
- Universitas Gadjah Mada, Indonesia
- Universitas Gadjah Mada, Indonesia
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Indexation |
Indexed by |
MyJurnal (2021) |
H-Index
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3 |
Immediacy Index
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0.000 |
Rank |
0 |
Indexed by |
Scopus 2020 |
Impact Factor
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CiteScore (0.2) |
Rank |
Q4 (Medicine (all)) |
Additional Information |
SJR (0.144) |
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