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Cholinesterase inhibition activity and molecular docking study of eugenol derivatives
Khairunisa Mohd Zamli1, Asnuzilawati Asari2, Kooi, Yeong Khaw3, Vikneswaran Murugaiyah4, Al-Rashida, Mariya5, Habsah Mohamad6, Hanis Mohd Yusoff7, Nurul Huda Abdul Wahab8, Hasnah Osman9.
The study was conducted to explore the anticholinesterase inhibition property of eugenol derived molecules. Ten eugenol derivatives were synthesized and evaluated for the inhibitory activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) by Ellman’s method. Most of the tested derivatives showed higher inhibition on BChE than AChE, however, their overall inhibitory activity was weak. In contrast, three derivatives (compounds 3,6,9) showed higher and good AChE inhibitory activity of more than 50% inhibition at 10 μg/mL. Among them, compound 9 bearing a ethyl substituent at para position of the benzoyl ring showed the most potent AChE inhibition, with IC50 of 5.64 μg/mL. Ligand-protein docking simulation was also performed for the most active derived molecules (compounds 3,6,9).
Affiliation:
- Universiti Malaysia Terengganu, Malaysia
- Universiti Malaysia Terengganu, Malaysia
- Universiti Sains Malaysia, Malaysia
- Universiti Sains Malaysia, Malaysia
- Forman Christian College, Pakistan
- Universiti Malaysia Terengganu, Malaysia
- Universiti Malaysia Terengganu, Malaysia
- Universiti Malaysia Terengganu, Malaysia
- Universiti Sains Malaysia, Malaysia
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Indexation |
Indexed by |
MyJurnal (2021) |
H-Index
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6 |
Immediacy Index
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0.000 |
Rank |
0 |
Indexed by |
Web of Science (SCIE - Science Citation Index Expanded) |
Impact Factor
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JCR (1.009) |
Rank |
Q4 (Multidisciplinary Sciences) |
Additional Information |
JCI (0.15) |
Indexed by |
Scopus 2020 |
Impact Factor
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CiteScore (1.4) |
Rank |
Q2 (Multidisciplinary) |
Additional Information |
SJR (0.251) |
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