The aim of this study is to investigate the effects of dietary papaya peel and baker’s yeast (Saccharomyces cerevisiae) as growth supplements for the silver barb (Barbodes gonionotus), their influence on the fish’s hematological values and disease resistance against Aeromonas hydrophila. The study comprised four experimental diets, namely a control (C); 4 % (w/w) papaya peel (P); 2 % (w/w) baker’s yeast (Y); and, 4 % (w/w) papaya peel plus 2% (w/w) baker’s yeast (PY). After eight weeks of feeding, the silver barb fed with PY diet had significantly higher values of final body weight (14.53±0.29 g/fish) and specific growth rate (SGR, 1.87±0.05 %/day) compared with the control (P<0.05). They also recorded an improved feed conversion ratio (FCR) (P<0.05). However, the C and P diets did not exhibit significant differences in FCR and SGR. During the feeding trial, no mortality was observed. Silver barbs on PY diet had significantly higher red blood cells (RBC) and white blood cells (WBCs) than the other diet groups (P<0.05). Intraperitoneal injection of 0.1 ml (0.5x107 CFU mL-1) A. hydrophila resulted in increased mortality, which was reduced with the intake of Y and PY diets. In conclusion, the P diet alone showed no differences in growth performance and haematological parameters when compared with the control. However, the dietary inclusion of baker’s yeasts may improve growth performance, as well as resistance to A. hydrophila. These results indicate that papaya peel and baker’s yeast may be used as feed additives for silver barb to produce better quality fish with protection from pathogenic infection.