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Alkaloid caulerpin and cytotoxic activity against NCL-H460 lung cancer cells isolated along with β-sitosterol from the Halimeda cylindracea Decaisne
Dini, Iwan1, Soekamto, Nunuk Hariani2, Firdaus3, Supratman, Unang4, Jalifah Latip5.
Alkaloid caulerpin (1), along with β-sitosterol (2), were isolated from the n-hexane extract of the macroalga Halimeda cylindracea Decaisne. The chemical structure was identified by a spectroscopic method including IR, MS, UV, NMR 1D, NMR 2D, and comparison with data of spectra previously reported. Compounds (1) and (2) were isolated for the first time from this macroalga. Compund (1) were evaluated for their cytotoxicity activity against NCL-H460 lung cancer cells in vitro and showed moderate activity with IC50 value of 20.05 μg/mL.
Affiliation:
- Universitas Negeri Makassar, Indonesia
- Universitas Hasanuddin, Makassar, Indonesia, Indonesia
- Universitas Hasanuddin, Makassar, Indonesia, Indonesia
- Universitas Padjadjaran, Jatinangor, Indonesia, Indonesia
- Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia, Malaysia
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MyJurnal (2021) |
H-Index
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6 |
Immediacy Index
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0.000 |
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0 |
Indexed by |
Web of Science (SCIE - Science Citation Index Expanded) |
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JCR (1.009) |
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Q4 (Multidisciplinary Sciences) |
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JCI (0.15) |
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Scopus 2020 |
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CiteScore (1.4) |
Rank |
Q2 (Multidisciplinary) |
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SJR (0.251) |
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