Mesoporous titania nanoparticles (MTN) was successfully prepared by microwave-assisted menthod. The performance of MTN was compared with degussa P25 (commercial TiO2) on photocatalytic degradation of 2-chlorophenol (2-CP). Both catalysts were characterized by XRD, FTIR, UV-Vis DRS and surface area analysis. The characterization data indicated that MTN has higher surface area and lower particle size than P25. The 2-CP was successfully degraded completely under UV light irradiation despite of having a slightly higher band-gap value compared with P25. This study demonstrated that MTN shows a good potential as a photocatalyst.