Introduction: The cumulative effect of nutrient deficiency in the elderly results in weakness and other morbidity factors so that it can have an impact on the quality of life of the elderly. The purpose of this study was to determine the relationship between protein intake and vitamin D with the quality of life of the elderly. Methods: This is a quantitative-study with a descriptive cross-sectional research design involving 146 elderly from the Klaten district Indonesian using a purposive random sampling method. Data on Protein intake and vitamin D intake was measured by 24 hours recall quesionare. Quality of life was measured by the WHOQOL-BREF questionnaire. Results: Test results show that intake of protein and vitamin D has a significant relationship with quality of life. The results of the logistic regression analysis as a whole influence of all variables on quality of life indicated by the value of R Square (0.248). It can be concluded that the variables tested affect the quality of life by 24.8% and there are 75.2% of other factors that affect quality of life. Conclusion: Elderly people who have adequate intake of protein and Vitamin D tend to have a better quality of life compared to older people with less intake.