Introduction: Thalassemia is a group of heterogeneous genetic disorders caused by a decreased rate of synthesis of α or β chains. In thalassemia, one or more globin chains are lacking in production. Hence, there is an excess of globin chains because there are no partners in the process of hemoglobin formation. This condition causes erythropoiesis to be ineffective and erythrocyte gives a picture of hypochromic anemia and because of decreased hemoglobin, erythrocytes become hypochromic and microcytic and many target cells are present. The purpose of this study was to determine the morphological description of erythrocytes in thalassemia patients who are members of the TPPAI branch in Kediri. Methods: Purposive Sampling was done in 20 respondents. Results: From this study the results obtained 100% microcytic anemia, 100% hypochromic, Poikilocytosis dominated target cells 100%, and basophil stippling was found to be 85%. Conclusion: of this study shows that the blood smear of patients with thalassemia is hypochromic microcytic anisopoikilocytosis that is dominated by target cells and the discovery basophil stippling.